Influence of target size on vertical gaze palsy in a pathologically proven case of progressive supranuclear palsy
Identifieur interne : 004061 ( Main/Exploration ); précédent : 004060; suivant : 004062Influence of target size on vertical gaze palsy in a pathologically proven case of progressive supranuclear palsy
Auteurs : Barry M. Seemungal [Royaume-Uni] ; Mary Faldon [Royaume-Uni] ; Tamas Revesz [Royaume-Uni] ; Andrew Lees (neurologue) [Royaume-Uni] ; David S. Zee [États-Unis] ; Adolfo M. Bronstein [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2003-07.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Aged, Atrophy, Brain (pathology), Brain (physiopathology), Brain Stem (pathology), Brain Stem (physiopathology), Case study, Electronystagmography, Electrooculography, Human, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Paralysis, Progressive, Pursuit, Smooth (physiology), Reflex, Vestibulo-Ocular (physiology), Saccades (physiology), Size, Size Perception (physiology), Supranuclear Palsy, Progressive (diagnosis), Supranuclear Palsy, Progressive (physiopathology), Supranuclear paralysis, Tauopathies (diagnosis), Tauopathies (physiopathology), Video Recording, improved vertical gaze palsy, progressive supranuclear palsy, target size, tau Proteins (analysis).
- MESH :
- chemical , analysis : tau Proteins.
- diagnosis : Supranuclear Palsy, Progressive, Tauopathies.
- pathology : Brain, Brain Stem.
- physiology : Pursuit, Smooth, Reflex, Vestibulo-Ocular, Saccades, Size Perception.
- physiopathology : Brain, Brain Stem, Supranuclear Palsy, Progressive, Tauopathies.
- Aged, Atrophy, Electronystagmography, Electrooculography, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Video Recording.
Abstract
We document a new oculomotor phenomenon in a patient with pathologically proven progressive supranuclear gaze palsy (PSP), namely that vertical gaze excursion improves with larger pursuit targets. We used computerised video‐oculography during vertical smooth pursuit eye movements (SPEM) of circular targets of diameter 0.16 degrees and 16 degrees, sinusoidally oscillating at 0.08 Hz (peak‐to‐peak amplitude 49 degrees). Increasing target size improved vertical gaze excursion from 10 degrees to 25 degrees. There was no concomitant increase in slow phase eye velocity. The findings could be explained by a potentiation of the position control mechanism of pursuit by target size due to increased activation of brainstem pursuit‐optokinetic pathways and to higher order attentional mechanisms. This observation may be useful in the clinical assessment of PSP patients with severe neck rigidity in whom the doll's head–eye manoeuvre cannot be performed by comparing the degree of vertical gaze palsy during smooth pursuit testing between at least two differently sized targets and observing whether there is a larger excursion in response to a large target such as a newspaper. © 2003 Movement Disorder Society
Url:
DOI: 10.1002/mds.10434
Affiliations:
- Royaume-Uni, États-Unis
- Angleterre, Grand Londres, Maryland
- Londres
- National Hospital for Neurology and Neurosurgery
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Le document en format XML
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We used computerised video‐oculography during vertical smooth pursuit eye movements (SPEM) of circular targets of diameter 0.16 degrees and 16 degrees, sinusoidally oscillating at 0.08 Hz (peak‐to‐peak amplitude 49 degrees). Increasing target size improved vertical gaze excursion from 10 degrees to 25 degrees. There was no concomitant increase in slow phase eye velocity. The findings could be explained by a potentiation of the position control mechanism of pursuit by target size due to increased activation of brainstem pursuit‐optokinetic pathways and to higher order attentional mechanisms. This observation may be useful in the clinical assessment of PSP patients with severe neck rigidity in whom the doll's head–eye manoeuvre cannot be performed by comparing the degree of vertical gaze palsy during smooth pursuit testing between at least two differently sized targets and observing whether there is a larger excursion in response to a large target such as a newspaper. © 2003 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Maryland</li></region><settlement><li>Londres</li></settlement><orgName><li>National Hospital for Neurology and Neurosurgery</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Seemungal, Barry M" sort="Seemungal, Barry M" uniqKey="Seemungal B" first="Barry M." last="Seemungal">Barry M. Seemungal</name></region><name sortKey="Bronstein, Adolfo M" sort="Bronstein, Adolfo M" uniqKey="Bronstein A" first="Adolfo M." last="Bronstein">Adolfo M. Bronstein</name><name sortKey="Faldon, Mary" sort="Faldon, Mary" uniqKey="Faldon M" first="Mary" last="Faldon">Mary Faldon</name><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name><name sortKey="Revesz, Tamas" sort="Revesz, Tamas" uniqKey="Revesz T" first="Tamas" last="Revesz">Tamas Revesz</name></country><country name="États-Unis"><region name="Maryland"><name sortKey="Zee, David S" sort="Zee, David S" uniqKey="Zee D" first="David S." last="Zee">David S. Zee</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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